Graft versus host disease (GVHD)
Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 23 November 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.
● Identified in autopsies of children with congenital immune deficiencies with GVHD of other organs (Hum Pathol 1994;25:908)
● To diagnose, must pay careful attention to pancreatic ducts
● Note: GVHD may occur post-pancreas transplant, involving skin and other organs (Transplantation 2006;82:127)
● Lymphocytes around large to medium ducts, damage to ductal epithelium (focal necrosis, reactive nuclear changes, inspissated secretions in duct lumens), and periductal edema (Histopathology 1989;14:121)
End of Pancreas > Pancreatitis > Graft versus host disease (GVHD)
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