Ovary tumor
Other tumors not specific to ovary
Hepatoid carcinoma

Author: Nalini Gupta, M.D. (see Authors page)

Revised: 29 June 2016, last major update March 2015

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Hepatoid carcinoma [title] ovary
Cite this page: Hepatoid carcinoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/ovarytumorhepatoid.html. Accessed November 24th, 2017.
Definition / general
  • Carcinoma with hepatoid differentiation, initially described in 1987 by Isikura and Scully (Cancer 1987;60:2775)
  • Appears to derive from ovarian surface epithelium
  • Called "hepatoid" based on two criteria:
Epidemiology
Sites
Clinical features
  • Presents as adnexal mass, often with progressive abdominal distension and lower abdominal pain
  • Highly aggressive, progresses rapidly with metastases in abdomen and occasionally to lungs, with a median survival of 2 years (Acta Obstet Gynecol Scand 2007;86:498)
Laboratory
  • High serum AFP and serum CA125
Radiology description
  • Solid-cystic unilateral or bilateral adnexal mass
Case reports
Treatment
  • Insufficient data regarding the optimal treatment, but surgery with ovarian-like cancer chemotherapy regimens, such as carboplatin and paclitaxel, is often used (Acta Obstet Gynecol Scand 2007;86:498)
Clinical images

Images hosted on other servers:
Missing Image

Two soft tissue masses

Missing Image

Right adnexal mass

Gross description
Microscopic (histologic) description
  • Resembles hepatocellular carcinoma, with tumor cells arranged in sheets, nests or trabeculae
  • Cells have distinct borders, moderate to abundant eosinophilic cytoplasm, cytoplasmic PAS+ hyaline globules
Microscopic (histologic) images

Images hosted on Pathout server:
Missing Image

Abundant eosinophilic cytoplasm

Missing Image

Hepatoid component (left)

Missing Image

AFP+



Images hosted on other servers:
Missing Image

Sheets, nests and trabeculae

Missing Image

Sinusoidal arrangement of vascular channels

Missing Image

AFP+

Missing Image

AFP, p53, CK7, α inhibin

Missing Image

HepPar1+

Positive stains
Negative stains
Molecular / cytogenetics description
  • Albumin mRNA by in situ hybridization
Differential diagnosis