Chronic Myeloid Neoplasms
MDS / MPN
Chronic myelomonocytic leukemia with eosinophilia

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 9 March 2017, last major update August 2011

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PubMed Search: Chronic myelomonocytic leukemia eosinophilia

Cite this page: Chronic myelomonocytic leukemia with eosinophilia. PathologyOutlines.com website. http://pathologyoutlines.com/topic/myeloproliferativecmmleosinophilia.html. Accessed October 21st, 2017.
Clinical features
  • Rare (< 2% of cases); < 50 cases reported to date
  • Associated with t(5;12)(q33;p13) - PDGFR beta and TEL genes (Blood 1995;85:2848)
  • Peripheral eosinophil count > 1500 per microliter; occasionally has only bone marrow eosinophilia
  • Men, median age 55 years, range 18 - 68 years
  • Usually fatal, often due to blast crisis with additional cytogenetic aberrations (Am J Clin Pathol 2006;125:49)
Case reports
Treatment
Microscopic (histologic) description
  • Peripheral blood: marked leukocytosis with eosinophilia (80%), monocytosis (60%) and basophilia (40%)
  • Bone marrow: hypercellular
Microscopic (histologic) images

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Various images

Molecular / cytogenetics description

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Karyotype