Chronic Myeloid Neoplasms
Myelodysplastic syndromes
5q- syndrome

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 2 March 2017, last major update August 2011

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: 5q- syndrome [title]

Cite this page: 5q- syndrome. PathologyOutlines.com website. http://pathologyoutlines.com/topic/myeloproliferative5qminus.html. Accessed April 23rd, 2017.
Definition / General
  • Subtype of refractory anemia with good prognosis
  • Stable clinical course but often transfusion dependent causing frequent hemochromatosis
  • Usually elderly women
  • 10% progress to AML
Laboratory
  • Moderate to severe macrocytic anemia, thrombocytosis in 50%
Treatment
Micro Description
  • Bone marrow biopsy: usually hypercellular or normocellular, erythroid hypoplasia, increased clusters of megakaryocytes with abundant cytoplasm but hypolobulated or nonlobated nuclei
  • Bone marrow smear: reduced erythroblasts, megakaryocyte hyperplasia with nuclear hypolobulation; either granulocyte or megakaryocyte dysplasia but not both, < 5% blasts in BM and < 1% blasts in PB, no Auer rods
Micro Images

Images hosted on PathOut server:


Peripheral blood:

Blast and numerous platelets (platelet count was 567K)


Bone marrow biopsy:

Increased megakaryocytes
with overall increased PAS+
cytoplasm, nuclear hypolobulation


Bone marrow smear:

Two small megakaryocytes
have granular cytoplasm and
nonlobulated nuclei,
otherwise classified as RAEB


Images hosted on other servers:


Nature Images


Bone marrow biopsy:

Case with JAK2 V617F mutation

Molecular / Cytogenetics Description
  • Interstitial deletions of 5q12 to 5q32
  • If additional cytogenetic abnormalities are present (except loss of Y chromosome), do NOT categorized as 5q- MDS
Molecular / Cytogenetics Images

Images hosted on other servers:

Karyotypes