Diffuse thymic fibrosis
Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 20 March 2013, last major update December 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Uncommon disorder with no/Limited symptoms; may have dyspnea, cough or hemoptysis
● Area of diffuse fibrosis varies from 3.5 to 17 cm, confined to anterior mediastinum
● Unknown etiology; altered immunity or infection may play a role
● Males and females, mean age 48 years
● Diffuse fibrosis with variable collagen deposition, lymphoplasmacytic infiltrates and involution/atrophy of thymus
● May show IgG4+ plasma cells and focal obliterative phlebitis (Am J Surg Pathol 2010;34:211)
End of Mediastinum > Thymus > Diffuse thymic fibrosis
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