Clear cell thymic carcinoma
Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 3 March 2013, last major update December 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Rare; clear cytoplasm due to either glycogen or degenerative changes
● Almost always fatal
● 42 year old man (Gen Thorac Cardiovasc Surg 2010;58:98)
● Lobular or occasionally sheet-like growth pattern of polygonal cells with clear cytoplasm, rather bland nuclear features, round vesicular nuclei, prominent nucleoli; delicate fibrovascular stroma (Am J Surg Pathol 1995;19:835)
● No blood lakes, no mucin
Large amount of glycogen-rich cytoplasm creates superficial resemblance to renal cell carcinoma
Large cells with abundant optically clear cytoplasm
● Metastatic renal cell carcinoma
End of Mediastinum > Thymic carcinoma > Clear cell thymic carcinoma
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