Lymphoma and plasma cell neoplasms - Plasmacytoma
Plasma cell neoplasms

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 3 April 2017, last major update March 2011

Copyright: (c) 2001-2017,, Inc.

PubMed Search: plasmacytoma b cell lymphoma

Cite this page: Plasmacytoma. website. Accessed September 22nd, 2017.
Definition / general
  • Plasma cell neoplasm that forms discrete mass
Clinical features
  • Constitutes 3 - 5% of plasma cell neoplasms
  • Isolated plasma cell neoplasm, usually of bone or soft tissue (oropharynx), composed of terminally differentiated B cells
  • Either solitary plasmacytoma of bone, extramedullary plasmacytoma or primary lymph node plasmacytoma

Extramedullary plasmacytoma:
  • Arises outside bone marrow; often in nasal cavity, nasopharynx, sinuses, oropharynx, lung or any other body site
  • May recur locally, but only infrequently progresses to myeloma, less often than solitary plasmacytomas of bone
  • Morphologic features similar to solitary plasmacytoma of bone

Primary lymph node plasmacytoma:
  • Rare, must exclude metastatic multiple myeloma (40% of high stage myelomas metastasize to lymph nodes), metastatic upper respiratory tract plasmacytomas (15% metastasize to cervical lymph nodes) and Castleman disease
  • Often involves cervical nodes, mean 5 cm, 40% had serum monoclonal proteins, most patients had localized disease and were cured after local excision or radiation, similar to other extramedullary plasmacytomas (Am J Clin Path 2001;115:119)
Case reports
  • Local radiation
Gross images

Images hosted on other servers:

Metastasis to myocardium

Microscopic (histologic) description
  • Lymph nodes: effacement by mature plasma cells, with no / rare lymphocytes or immunoblasts
Microscopic (histologic) images

Images hosted on other servers:

Atypical plasma cells

Metastases to myocardium

Various images

Cutaneous plasmacytoma

Plasmablastic plasmacytoma

Differential diagnosis
  • Myeloma: plasma cells are usually more anaplastic
  • Plasmacytosis: no light chain restriction of plasma cells