Lymphoma and plasma cell neoplasms
Other
Specific examples of LHIV (HIV associated Lymphoma)

Author: Dragos Luca, M.D. (see Authors page)

Revised: 14 March 2017, last major update January 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: "HIV associated lymphoma"

Cite this page: Specific examples of LHIV. PathologyOutlines.com website. http://pathologyoutlines.com/topic/lymphomanonBAIDSvariants.html. Accessed July 24th, 2017.
AIDS associated anaplastic large cell lymphoma

Case reports:

Micro images:

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Left: 16 year old boy; Right: 46 year old man


AIDS associated Burkitt and Burkitt-like lymphoma

Definition / General:
  • Features of Burkitt lymphoma or Burkitt-like lymphoma
  • 30% of LHIV
  • Plasmacytoid differentiation – 2/3 of cases (relatively specific to AIDS patients); medium sized cells, abundant basophilic cytoplasm, eccentric nucleus, centrally located prominent nucleolus, cytoplasmic Ig, 50 - 70% EBV+
  • Usual morphology – 1/3 of cases (30% EBV+)

AIDS associated cutaneous lymphoma

Definition / General:
  • Presents as solitary nodule / tumor in severely immunocompromised patients with low CD4 count
  • Death due to immunosuppression, not spread of lymphoma (Am J Surg Pathol 1999;23:1208)
  • Types: diffuse large B cell lymphoma, CD30+ T cell lymphoma, mycosis fungoides, anaplastic large cell lymphoma (ALK negative), HHV8 negative


Treatment:
  • Avoid aggressive immunosuppression

AIDS associated diffuse large B cell lymphoma

Definition / General:
  • Associated with end stage HIV, severe combined immunodeficiency, bone marrow transplantation, solid organ transplantation, EBV infection
  • May regress with restoration of T cell immunity
  • Centroblastic: represent 25 - 30% of LHIV, most LHIV diffuse large B cell lymphomas, 30% are EBV+
  • Immunoblastic: represent 10% of LHIV; > 90% immunoblasts and usually show plasmacytoid features, 90% are EBV+; often late occurrence, usual subtype for primary CNS lymphoma


Case reports:

Micro images:

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Left: 25 year old woman; Right: 38 year old man


AIDS associated Hodgkin lymphoma

Definition / General:
  • Frequently involves bone marrow; occasionally only involves bone marrow
  • Median survival 4 months (range, 2 - 118 months) in bone marrow only cases
  • EBV+ in nearly all cases (EBV LMP1 and EBER positive)


Micro description:
  • Reed-Sternberg cells present, most cases are classic Hodgkin lymphoma mixed cellularlity or lymphocyte depleted, occasionally nodular sclerosis


Micro images:

Images hosted on other servers:

Various images



Additional references:
AIDS associated MALT lymphoma

Definition / General:
  • Primary pulmonary lymphomas are rarer than secondary spread to lungs
  • Usually in HIV+ children, rare in adults


Case reports:

Micro images:

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Various images


AIDS associated NK cell lymphoma, nasal type

Case reports:

Micro images:

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Left/middle: mediastinal mass; Right: nasopharyngeal tumor


AIDS associated peripheral T cell lymphoma

Definition / General:
  • Less common than B cell lymphoma


Case reports:

Gross / Micro images:

Images hosted on other servers:

32 year old man with intravascular T cell lymphoma in appendix

37 year old woman with GI bleeding

62 year old man presenting with left ventricular rupture



Positive stains:

Negative stains:
  • B cell markers


Molecular description:
  • T cell receptor gamma chain gene rearrangement

AIDS associated plasmablastic lymphoma


AIDS associated polymorphic B cell lymphoproliferative disorders

Definition / General:
  • Rare, < 5% of LHIV; indolent if benign, aggressive if high grade
  • Morphologically similar to posttransplant lymphoproliferative disorders
  • Arise in lymph nodes, lungs, other sites
  • EBV may play a role in pathogenesis


Case reports:

Micro description:
  • Diffuse growth of polymorphic lymphocytes with variable plasmacytic differentiation, atypia and atypical immunoblasts
  • Numerous mitoses, extensive necrosis and architectural distortion


Micro images:

Images hosted on other servers:

8 year old girl with EBV+ CNS lymphoma



Positive stains:

Additional references:
AIDS associated primary effusion lymphoma