Lymphoma and plasma cell neoplasms
Non-Hodgkin lymphoma
Chemotherapeutic atypia

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 3 March 2017, last major update February 2011

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PubMed Search: chemotherapeutic atypia

Cite this page: Chemotherapeutic atypia. PathologyOutlines.com website. http://pathologyoutlines.com/topic/lymphomachemo.html. Accessed May 24th, 2017.
Definition / general
  • Chemotherapeutic agents, particularly alkylating agents, can induce bizarre epithelial atypia
  • Observed in lower respiratory tract and sinonasal tract
  • Includes patients treated for leukemia and myeloma
Microscopic (histologic) description
  • Striking nuclear enlargement, hyperchromasia and pleomorphism
  • Changes may be full thickness, and be associated with squamous metaplasia
Differential diagnosis