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Lymphoma - B cell neoplasms

Non-Hodgkin Lymphoma

Chemotherapeutic atypia

Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 8 February 2011, last major update February 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.


● Chemotherapeutic agents, particularly alkylating agents, can induce bizarre epithelial atypia
● Observed in lower respiratory tract and sinonasal tract
● Includes patients treated for leukemia and myeloma

Micro description

● Striking nuclear enlargement, hyperchromasia and pleomorphism
● Changes may be full thickness, and be associated with squamous metaplasia

Differential diagnosis

● Dysplastic appearance is common, particularly in frozen sections (Am J Surg Pathol 2001;25:652)

End of Lymphoma - B cell neoplasms > Non-Hodgkin Lymphoma > Chemotherapeutic atypia

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