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Lymphoma - B cell neoplasms

Classification Systems - Historical

Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 12 February 2011, last major update February 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.


Rappaport classification: 1956, revised 1966 (Cancer Res 1966;26:1082); developed before lymphocytes were classified as B and T cells; includes well-differentiated lymphocytic lymphoma, poorly differentiated lymphocytic lymphoma and histiocytic lymphoma; SEER table; University of Virginia table; note - Wikipedia incorrectly calls this the Rapporteur classification

Lukes and Collins classification, 1974 (Cancer 1974;34(4 Suppl):1488); classified non-Hodgkin's lymphomas as B cell, T cell, histiocytic and unclassifiable types; University of Virginia table

Working Formulation: 1982; classified as low, intermediate or high grade; nodular vs. diffuse; small, large or mixed tumor cell size (Cancer 1982;49:2112, free full text); SEER table; Wikipedia; University of Virginia table

Kiel classification: European system used in 1980-1990ís, based on cellular morphology and relationship to normal lymphoid cells; proposed by Karl Lennert in 1974 (link), SEER table; University of Virginia table

REAL (Revised European American Lymphoma): integrates clinical, morphologic, immunohistochemical and molecular characteristics; includes non Hodgkin's lymphoma, lymphocytic leukemias, plasma cell neoplasms; excludes histiocytic neoplasms; tumors are not classified as low grade / high grade since one entity could have both types (Blood 1994;84:1361); SEER table

WHO classification: current classification system; click here (separate topic)

End of Lymphoma - B cell neoplasms > Classification Systems - Historical

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