Lymphoma and plasma cell neoplasms
B cell lymphoma subtypes
Mantle cell lymphoma - Blastoid variant

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 3 April 2017, last major update February 2011

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PubMed Search: mantle cell lymphoma blastoid variant

Cite this page: Mantle cell lymphoma - Blastoid variant. PathologyOutlines.com website. http://pathologyoutlines.com/topic/lymphomaMCLblastoid.html. Accessed April 24th, 2017.
Clinical Features
  • Median age 63 years, range 40 - 79 years; 80% men
  • Moderate to marked leukocytosis
  • Aggressive behavior
Case Reports
Micro Description
  • Diffuse, nodular or mantle zone pattern
  • Higher grade histologic features than classic mantle cell
  • Either (a) lymphoblastic with intermediate size cells containing round nuclei and finely disbursed chromatin, marked mitotic activity and leukemic involvement, resembling CLL / SLL or AML; or (b) pleomorphic with heterogeneous larger cells with deeply indented, pleomorphic nuclei and variably prominent nucleoli, high proliferation rate, often with striking staining of chromatin due to tetraploid clones, resembling diffuse large B cell lymphoma
Micro Images

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Cases with prominent nucleoli

Various images

Fig. A: starry sky pattern; fig. B: immature chromatin and high mitotic rate

Cytology Images

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Left: bone marrow aspirate smear; right: peripheral blood smear

Positive Stains
Negative Stains
Molecular / Cytogenetics Description
  • t(11;14)
  • Blastoid variant is also associated with c-MYC and 8q24 abnormalities (Mod Pathol 2002;15:1266)
  • Usually complex karyotypes with 3+ additional chromosomal abnormalities, most commonly chromosome 13; also 18, 17, 8 and 3 (Hum Pathol 2003;34:1022)
Molecular / Cytogenetics Images

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Left: BCL1 by PCR; right: cyclin D1 mRNA by RT-PCR

Differential Diagnosis