Lung tumor
Lymphoma and lymphoid infiltrates
Waldenström macroglobulinemia

Author: Deepali Jain, M.D. (see Authors page)

Revised: 3 January 2017, last major update September 2012

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: Waldenstrom macroglobulinemia pulmonary
Table of Contents
Definition / general | Diagnosis
Cite this page: Waldenström macroglobulinemia. PathologyOutlines.com website. http://pathologyoutlines.com/topic/lungtumorwaldenstrom.html. Accessed December 14th, 2017.
Definition / general
  • B-cell neoplasm (usually lymphoplasmacytic lymphoma) plus serum IgM monoclonal paraprotein
  • Usually elderly patients with indolent clinical course
  • Median survival 5 years
  • Involves bone marrow (100%), liver, spleen, lymph nodes (15 - 20%); lung is an unusual site (Am J Surg Pathol 2003;27:1104)
  • Hyperviscosity syndrome in 15%
Diagnosis
  • Serum protein electrophoresis to detect monoclonal paraprotein