Lung tumor
Other malignancies
Pulmonary blastoma

Author: Deepali Jain, M.D. (see Authors page)

Revised: 4 January 2017, last major update September 2012

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: pulmonary blastoma
Cite this page: Pulmonary blastoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/lungtumorpulmonaryblastoma.html. Accessed May 29th, 2017.
Definition / general
  • Rare tumor composed of mixture of immature epithelial and mesenchymal tissue resembling fetal lung tissue
  • Also called embryoma
  • Usually adults (mean age 43 years), 20% occur in patients < age 20 years
  • Metastases common
  • 2 / 3 die within 2 years
  • See also pleuropulmonary blastoma - cystic tumor of pleura and lung
Case reports
Gross description
  • Peripheral, solitary, well circumscribed, large
Microscopic (histologic) description
  • Biphasic tumor in which epithelial and mesenchymal components have a primitive, "fetal-type" appearance
  • Well formed tubular glands surrounded by cellular stroma of "embryonal" appearance
  • Resembles Wilms' tumor and fetal lung at 10 - 16 weeks
  • Glandular cells are tall, columnar, often with clear cytoplasm and subnuclear and supranuclear cytoplasmic vacuoles
  • Morules with ground glass nuclei are common
  • Stroma may differentiate towards striated muscle, smooth muscle, cartilage
  • In infants / children, epithelial component is benign appearing or minimal
Microscopic (histologic) images

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Biphasic tumor

Positive stains
  • PAS (glycogen in epithelial cells)
Molecular / cytogenetics description