Lung tumor
Other carcinoma
Large cell neuroendocrine carcinoma

Author: Deepali Jain, M.D. (see Authors page)

Revised: 22 December 2016, last major update September 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: large cell neuroendocrine carcinoma lung
Cite this page: Large cell neuroendocrine carcinoma. website. Accessed October 22nd, 2017.
Definition / general
  • Aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics; characterized by high mitotic activity and necrotic change (WHO)
  • Rosai: resembles non-small cell carcinoma, but on closer inspection has a hint of neuroendocrine architecture confirmed by special stains
  • More likely to develop recurrent lung cancer and have shorter actuarial survival than patients with other histologic types of NSCLC, even in those with stage I disease (Cancer Control 2006;13:270)
Microscopic (histologic) description
  • Larger tumor cells than atypical carcinoid, high nuclear grade, increased mitotic activity (11+ per 10 HPF) and necrosis (Arch Pathol Lab Med 2010;134:1628)
  • Poorly developed neuroendocrine architecture with some pallisading or rosette-like structures present
  • Oncocytic neuroendocrine tumor: low grade or high grade; oncocytic features, but similar clinically to nononcocytic tumors (Hum Pathol 2011;42:578)
Microscopic (histologic) images

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Phosphohistone H3

Metastases from lung primaries

Positive stains