Lung
Adenocarcinoma
Fetal
Author: Deepali Jain, M.D.
Last author update: 1 September 2012
Last staff update: 22 December 2020
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: fetal adenocarcinoma lung
Table of Contents
Definition / general | Microscopic (histologic) description | Microscopic (histologic) images | Cytology description | Cytology imagesCite this page: Jain D. Fetal. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lungtumoradenofetal.html. Accessed April 24th, 2024.
Definition / general
- Rare tumor resembling fetal lung in pseudoglandular stage
- Either high grade or low grade
- May be a variant of pulmonary blastoma without malignant mesenchymal components
- Low grade tumors associated with upregulation of Wnt signaling pathway (Mod Pathol 2002;15:617)
- High grade variant is very aggressive
Microscopic (histologic) description
- Irregular tubular structures of columnar epithelial cells with clear cytoplasm and oval nuclei, optically clear nuclei rich in biotin
- Resembles fetal lung in pseudoglandular stage
- High grade: disorganized glands, large vesicular nuclei, prominent nucleoli, pronounced anisonucleosis, transition to conventional adenocarcinoma, broad areas of necrosis, desmoplastic stroma, p53+, AFP+, no morules (Am J Surg Pathol 1998;22:399)
Microscopic (histologic) images
Images hosted on other servers:
Well differentiated tumor
Cytology description
- Low grade tumors: subnuclear vacuoles with tigroid features, small, uniform, round nuclei, morules, neuroendocrine differentiation in glandular epithelial cells (Am J Clin Pathol 2010;134:894)
Cytology images
Images hosted on other servers:
Various images
