Lung tumor
Adenocarcinoma
Acinar cell carcinoma

Author: Deepali Jain, M.D. (see Authors page)

Revised: 20 December 2016, last major update September 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: acinar cell carcinoma lung
Cite this page: Acinar cell carcinoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/lungtumoracinic.html. Accessed March 27th, 2017.
Definition / General
  • Malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns (WHO)
  • Bronchial gland tumor resembling salivary gland tumor, well circumscribed, 1-5 cm, with predominantly low grade malignant acinar cells (note difference from WHO definition)
  • Very rare at this site, usually in parotid gland, less commonly in submandibular and sublingual glands
  • Also known as Fechner tumor
  • May arise from pluripotent cells of tracheobronchial submucosal serous and mucus glands
Case Reports
Treatment
  • Surgical excision
Micro Description
  • Low grade tumor with acinar, oncocytic, papillocystic patterns (Am J Surg Pathol 1992;16:1039)
  • Predominantly acinar cells, also ductal cells, myoepithelial cells, reserve / stem cells
  • Solid areas recapitulate salivary gland acinar differentiation with large polyhedral cells containing abundant granular cytoplasm, round bland nuclei
  • Microcystic areas recapitulate terminal duct-acinar unit
  • In contrast to salivary gland tumor, no / rare perineural invasion
  • No nuclear pleomorphism, no mitotic activity
Micro Images

Images hosted on other servers:

Acinic cell carcinoma: primary and recurrent tumor

Salivary gland acinic cell carcinoma: various images

Positive Stains
  • Cytokeratin, EMA
Negative Stains
  • Amylase
Electron Microscopy Description
  • No melanosomes, no abundant cytoplasmic glycogen, no neurosecretory granules, no abundant mitochondria or fat globules
Differential Diagnosis