Lung tumor
Other carcinoma
Lymphoepithelioma-like carcinoma

Author: Deepali Jain, M.D. (see Authors page)

Revised: 27 December 2016, last major update September 2012

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PubMed Search: lymphoepithelioma-like carcinoma lung
Cite this page: Lymphoepithelioma-like carcinoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/lungtumorLEL.html. Accessed June 27th, 2017.
Definition / general
  • Rare tumor in lung, more commonly in Asians
  • In Asians, usually women, non-smokers, with EBV+ tumors (Am J Surg Pathol 2002;26:715)
  • In Caucasians, usually EBV-
  • Tumor size may correlate with EBV serology titer
  • May have better prognosis than other non-small cell carcinomas of lung (Cancer 2012;118:4748)
Case reports
Gross description
  • Well circumscribed nodules
Microscopic (histologic) description
  • Syncytial growth of epithelial cells with large vesicular nuclei, prominent eosinophilic nucleoli, accompanied by marked CD8+ lymphocytic infiltration
  • Predominantly pushing borders, permeative interface with adjacent lung
  • Occasional amyloid deposition
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
  • EBV, BCL2; variable EBER-1, LMP; patchy keratin
Negative stains
Differential diagnosis