Lung - nontumor
Infections
Strongyloides

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 27 February 2017, last major update September 2011

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed search: Strongyloides [title] pulmonary

Cite this page: Strongyloides. PathologyOutlines.com website. http://pathologyoutlines.com/topic/lungnontumorstrongyloides.html. Accessed June 26th, 2017.
Clinical features
  • Endemic in Southeastern United States, South America, Southeast Asia and Sub-Saharan Africa
  • Infection occurs when larvae in soil penetrate the skin and travel to the lung via the venous circulation; the worms then travel up the trachea to the oropharynx and are swallowed setting up infection in the small intestine
  • Female worms in the small intestinal mucosa produce eggs asexually (parthenogenesis) that are passed to the soil where they hatch to continue cycle of infection
  • Larvae hatched in the intestines may penetrate the colonic mucosa to travel to the lung to reinitiate infection (autoinfection)
  • Disease usually affects the gastrointestinal tract
  • In immunocompromised patients, severe disease with large burden of parasites may occur; patients may present with alveolar hemorrhage (Prim Care Respir J 2009;18:337)
  • May predispose to invasive infections caused by enteric organisms (Am J Clin Pathol 2007;128:622)
Diagrams / tables

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Life cycle

Microscopic (histologic) description
  • In the lung, eosinphilic pneumonia with hemorrhage may occur
  • Worms may be found in airways, alveoli and blood vessels
Microscopic (histologic) images

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Small bowel infection



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Small bowel infection

Cytology images

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Bronchial wash

Pap stain

Diff-Quik



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Bronchial wash

BAL fluid