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Hantavirus pneumonia

Reviewer: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 5 September 2011, last major update September 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

Clinical features

● Zoonosis transmitted by feces from infected rodents (Emerg Infect Dis 2009;15:561)
● Severe pulmonary disease, often in Southwest US; 25-35% mortality
● Symptoms eventually resolve in almost all survivors (Lung 2010;188;387)
● Epidemic disease occurred in Southwestern US in 1993 (Centers for Disease Control); sporadic cases have occurred since then
● Diagnosis confirmed by immunohistochemistry, serology, PCR, electron microscopy

Clinical images

Cotton Rat (Sigmodon hispidus)

Micro description

● Causes interstitial pneumonitis with mononuclear infiltrate, edema, focal hyaline membranes, pleura effusions
● Atypical lymphocytes in pulmonary vasculature may mimic lymphoma

Micro images

Interstitial pneumonitis and intraalveolar edema

Various images

Electron microscopy images

Transmission electron micrograph of Sin Nombre Hantavirus

Additional references


End of Lung-nontumor > Infections > Hantavirus pneumonia

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