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Liver and intrahepatic bile ducts-nontumor

Infectious (non-viral) disorders

Visceral larva migrans

Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 10 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.


● Due to Toxocara canis, Toxocara catis (dog and cat worms) or Capillaria hepatica
● Lesions in liver, lung and other viscera with extreme chronic eosinophilia
● Toxocara larva are 400 x 15-20 microns
● All ages, male and female
● Associated with inadequate sewage and presence of dogs and cats
● 60% asymptomatic; also fever, abdominal pain
● Serial sections, immunostains or serology may be required for diagnosis

Gross description

● 74% have visible lesion, 80% multiple, often in subcapsular right lobe, 3-10 mm, gray-white

Micro description

● Multiple palisading granulomas with central necrosis surrounding by eosinophils, chronic inflammatory cells and neutrophils, granulomas often periportal
● Charcot-Leyden crystals (44%)
● Parasites present on H&E in only 25%

Positive stains

● Toxocaris antibody staining of macrophages, Biebrich scarlet stain (for eosinophils)

Additional references

Am J Surg Pathol 2001;25:1316, Dig Liver Dis 2006;38:511

End of Liver and intrahepatic bile ducts-nontumor > Infectious (non-viral) disorders > Visceral larva migrans

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