Liver and intrahepatic bile ducts - tumor
Hepatocellular carcinoma
Sarcomatoid variant

Author: Deepali Jain, M.D. (see Authors page)

Revised: 27 November 2017, last major update February 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Sarcomatoid hepatocellular carcinoma[TIAB]

Cite this page: Jain, D. Sarcomatoid variant of hepatocellular carcinoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/livertumorsarcomatoid.html. Accessed December 15th, 2017.
Definition / general
  • Also called spindle cell hepatocellular carcinoma, pseudosarcomatous
  • Diffuse collection of spindle cells resembling fibrosarcoma or malignant fibrous histiocytoma but with classic hepatocellular carcinoma is also present
  • Note: 1 - 9% of all hepatocellular carcinomas have prominent sarcomatoid pattern
Clinical features
  • Mean age 62 years old, range 46 - 84 years, usually men
  • Metastases common, often to lung and lymph nodes
  • Most patients die of disease
Gross images

Images hosted on other servers:

Various images

Microscopic (histologic) description
  • Diffuse collection of spindle cells resembling fibrosarcoma or malignant fibrous histiocytoma
  • Classic hepatocellular carcinoma is also present
  • May have pleomorphic and osteoclast-like giant cells, chondroid differentiation (Pathol Int 2000;50:919)
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Differential diagnosis
  • Carcinoma with foci of spindle shaped epithelial cells
  • Collision tumor