Home   Chapter Home   Jobs   Conferences   Fellowships   Books


Liver and intrahepatic bile ducts - Tumor

Benign tumors

Reactive bile ductule proliferation

Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.


● Bile ductular proliferation due to ductular metaplasia of hepatocytes and from proliferation of pre-existing bile ductules
● Associated with cirrhosis, submassive hepatic necrosis, biliary tract disorders, atrophy and focal nodular hyperplasia

Gross description

● Often multiple irregular nodules

Micro description

● Periductular neutrophils common
● No angulated structures, usually no dense fibrosis (except with atrophy), variable bile in portal tract or periportal area

Positive stainss

● Neuroendocrine stains (Am J Pathol 1990;137:1019)

Differential diagnosis

● Adenocarcinoma: particularly confusing after chemotherapy, has more severe atypia with irregular nuclear membranes, prominent nucleoli, hyperchromasia, increased N/C ratio, desmoplasia, infiltrative cells
● Bile duct adenoma: solitary, subcapsular, with collapsed lumina, prominent lymphocytes
● Bile duct hamartoma: angulated ducts embedded in sclerotic stroma

End of Liver and intrahepatic bile ducts - Tumor > Benign tumors > Reactive bile ductule proliferation

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).