Liver and intrahepatic bile ducts - tumor
Leukemia / lymphoma
Lymphoma - primary

Author: Deepali Jain, M.D. (see Authors page)

Revised: 28 November 2017, last major update February 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Primary lymphoma of the liver[TI]

Cite this page: Jain, D. Lymphoma - primary. PathologyOutlines.com website. http://pathologyoutlines.com/topic/livertumorlymphomaprimary.html. Accessed December 12th, 2017.
Definition / general
  • Rare; ~ 100 cases reported; < 1% of all extranodal lymphomas, 0.01% of non-Hodgkin lymphoma (Cancer 1972;29:252)
  • Clinical disease due mainly to liver involvement, without systemic disease or distal lymphadenopathy
  • 75% men, median age 55 years but all ages
  • Symptoms: abdominal pain and hepatomegaly; may present with liver failure; associated with cirrhosis, immunocompromise
  • Also associated with HBV (3 - 30%, Jpn J Cancer Res 2002;93:471), HCV (40 - 60%, Clin Lymphoma Myeloma 2006;6:273) and EBV
  • Pathogenesis of HCV associated lymphoma involves chronic antigen stimulation of B cell populations (J Clin Pathol 2007;60:1378)
  • Most common subtype is diffuse large B cell lymphoma
  • Two year survival of 66%; poor survival if cirrhosis or immunocompromise
Gross description
  • Large mass or multiple masses (30 - 35%) resembling carcinoma
  • Variable hemorrhagic and necrosis
Microscopic (histologic) description
  • May have diffuse sinusoidal infiltration
Differential diagnosis