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Liver and intrahepatic bile ducts - Tumor

Benign tumors


Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.


● Solitary nodule resembling leiomyoma elsewhere; may resemble metastatic well differentiated leiomyosarcoma

Clinical features

● For diagnosis, should be no primary leiomyomas elsewhere in body
● Arises from mesenchymal tissue of the liver - smooth muscle cells of vessels or biliary tree
● Higher prevalence in patients with immunosuppression or organ transplantation (HIV or EBV infection)
● Metastasis and recurrence may develop in histologically benign leiomyomas

Micro description

● Spindle cell proliferation with elongated nuclei, eosinophilic cytoplasm; may have abundant T cells
● No nuclear atypia, hemorrhage or necrosis
● Criteria for malignancy: increased mitotic rate (>1/10 high power fields), cellular atypia with nuclear pleomorphism, dense cellularity and degenerative changes

Differential diagnosis

● GIST: cells don't resemble smooth muscle, CD117+

End of Liver and intrahepatic bile ducts - Tumor > Benign tumors > Leiomyoma

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