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Liver and intrahepatic bile ducts - tumor

Leukemia / lymphoma

Diffuse large B cell lymphoma

Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.

See also Lymphoma and plasma cell neoplasms chapter


● Most common non Hodgkin lymphoma of liver (Leuk Lymphoma 1998;29:293)

Case reports

● 56 year old man with intravascular lymphomatosis affecting liver, omentum and bone marrow (Arch Pathol Lab Med 1999;123:952)
● 67 year old man (Hepat Mon 2011;11:203)
● 70 year old man whose tumor has spindle cell component (Virchows Arch 2006;449:591)

Gross description

● Bulky tan-white mass

Micro images

Various images

Associated with Hepatitis C

Differential diagnosis

Age-related EBV-associated B-cell lymphoproliferative disorders
Follicular lymphoma, high grade: usually some classic follicular lymphoma component present, t(14;18)+; CD10+
Mantle cell lymphoma, blastoid variant: CD5+, CyclinD1+
Plasmablastic lymphoma: HIV+, immunoblastic morphology

End of Liver and intrahepatic bile ducts - tumor > Leukemia/lymphoma > Diffuse large B cell lymphoma

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