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Liver and intrahepatic bile ducts - Tumor

Benign tumors

Biliary adenofibroma

Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.


● Extremely rare (<25 reported cases) large solid cystic mass
● Age ranges from 21-79 years; no gender predilection
● Monosomy 22 in one case (Cancer Genet Cytogenet 1997;93:183)
● Appears to originate from interlobular or larger bile ducts
● Benign behavior to date, but may be premalignant

Case reports

● 47 year old woman (Am J Surg Pathol 2003;27:693)
● 79 year old man (Patholog Res Int 2010;2010:504584)

Micro description

● Microcystic and tubular structures lined by low columnar/cuboidal epithelium
● Luminal eosinophilic material, red blood cells, bile and dense fibrous stroma with spindle cells displaying mild nuclear pleomorphism; no/rare mitotic figures, no stromal invasion

Micro images

Various images

Positive stains

Epithelium: AE3, CAM5.2, CK7, CK19, CEA, EMA, D10, IF6, p53

Negative stains

● Alcian blue, vimentin, desmin

Differential diagnosis

Benign cystic mesothelioma
Biliary cyst
Biliary cystadenoma: larger, multiloculated cysts, mucinous epithelium with ovarian-type of stroma
Bile duct adenoma: incidental, small
von Meyenburg complex: smaller, usually multifocal, but similar staining pattern

End of Liver and intrahepatic bile ducts - Tumor > Benign tumors > Biliary adenofibroma

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