Liver and intrahepatic bile ducts - tumor
Benign tumors / conditions
Biliary adenofibroma

Author: Deepali Jain, M.D. (see Authors page)

Revised: 14 November 2017, last major update February 2012

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PubMed Search: Biliary adenofibroma

Cite this page: Jain, D. Biliary adenofibroma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/livertumorbiliaryadenofibroma.html. Accessed December 15th, 2017.
Definition / general
  • Extremely rare (< 25 reported cases) large solid cystic mass
  • Age ranges from 21 - 79 years; no gender predilection
  • Monosomy 22 in one case (Cancer Genet Cytogenet 1997;93:183)
  • Appears to originate from interlobular or larger bile ducts
  • Benign behavior to date but may be premalignant
Case reports
Microscopic (histologic) description
  • Microcystic and tubular structures lined by low columnar / cuboidal epithelium
  • Luminal eosinophilic material, red blood cells, bile and dense fibrous stroma with spindle cells displaying mild nuclear pleomorphism; no / rare mitotic figures, no stromal invasion
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Negative stains
Differential diagnosis