Liver and intrahepatic bile ducts - tumor
Leukemia / lymphoma
Mucosal associated lymphoid tissue (MALT) lymphoma

Author: Deepali Jain, M.D. (see Authors page)

Revised: 30 November 2017, last major update February 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Mucosal associated lymphoid tissue[TI] OR MALT[TI] lymphoma liver

See also: Lymphoma and plasma cell neoplasms chapter
Cite this page: Jain, D. Mucosal associated lymphoid tissue (MALT) lymphoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/livertumorMALT.html. Accessed December 15th, 2017.
Definition / general
  • Rare, < 50 cases reported; represents 3% of cases of hepatic lymphoma (Int J Hematol 2008;88:418)
  • Mean age 60 years, slight female predominance
  • Occasionally associated with liver cirrhosis, primary biliary cirrhosis, hepatitis B and hepatitis C infection
Radiology images

Images hosted on PathOut server:

Case of the Week #260:

CT scan

Case reports
Treatment
  • Local excision; tumor is indolent
Gross images

Images hosted on other servers:

Solitary or multiple tan, subcapsular nodule

Microscopic (histologic) description
  • Extensive diffuse sheets of small B cells in the interfollicular areas
  • Centrocyte-like cells surround reactive B cell follicles and form lymphoepithelial lesions with bile ducts (Am J Surg Pathol 1995;19:571, Mod Pathol 1998;11:404)
  • May arise in settings of chronic inflammation including viral hepatitis
  • Note: reactive follicles and lymphoepithelial lesions are nonspecific
Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #260:

H&E


CD20

BCL2

Ki67

Left to right: negative for CD5, CD10, cyclin D1
(staining of non-MALT cells only)



Images hosted on other servers:

Entrapping bile ducts

CD20

Atypical
lymphocytes
entrapping islands
of hepatocytes

Various images

Cytology images

Images hosted on PathOut server:

Case of the Week #260:

Fine needle aspirate

Molecular / cytogenetics description
  • t(11;18)(q21;q21), t(1;14)(p22;q23), t(14;18)(q32;q21), 37 and t(3;14)(p14.1;q32)
Differential diagnosis