Liver and intrahepatic bile ducts - tumor
Other malignancies
Lymphoepithelioma-like carcinoma

Author: Deepali Jain, M.D. (see Authors page)

Revised: 5 December 2017, last major update February 2012

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PubMed Search: Lymphoepithelioma-like carcinoma liver

Cite this page: Jain, D. Lymphoepithelioma-like carcinoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/livertumorLEL.html. Accessed December 15th, 2017.
Definition / general
  • Very rare type of hepatocellular carcinoma with pleomorphic tumor cells mixed with numerous lymphocytes; tumor cells tend to be small with focal syncytial growth; most cases are actually variant of cholangiocarcioma; usually EBV+
  • Better prognosis than hepatocellular carcinoma
Case reports
Microscopic (histologic) description
  • Cords and trabeculae of large polygonal epithelial cells with marked lymphocytic infiltrate
  • Blurred border at tumor margin; otherwise normal liver
Microscopic (histologic) images

Images hosted on other servers:

Various images

Biliary tumor

Positive stains
Negative stains
Differential diagnosis
  • Lymphoepithelioma-like cholangiocarcinoma: syncytial pattern of undifferentiated epithelial cells and glands in lymphocyte plasma cell rich stroma; presence of glands differentiates this from lymphoepithelioma-like carcinoma