Liver and intrahepatic bile ducts - nontumor
Biliary tract disease
Secondary biliary cirrhosis

Author: Komal Arora, M.D. (see Authors page)

Revised: 7 November 2017, last major update May 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Secondary biliary cirrhosis[TI]

Cite this page: Arora, K. Secondary biliary cirrhosis. PathologyOutlines.com website. http://pathologyoutlines.com/topic/liversecBC.html. Accessed December 14th, 2017.
Definition / general
  • Extrahepatic bile duct obstruction due to biliary atresia, choledochal cysts, cystic fibrosis, Alagille syndrome, gallstones, postsurgical stricture, carcinoma of pancreatic head or biliary tree
  • Symptoms and laboratory: same as primary biliary cirrhosis but no antimitochondrial antibodies
  • Secondary inflammation causes periportal fibrosis, scarring and nodule formation
Gross description
  • Yellow green, icteric discoloration of tissues and fluids
  • Hard, granular liver
Microscopic (histologic) description
  • Fibrosis divides liver into jigsaw-like pattern
  • Septa contain large and small bile ducts with inspissated pigment
  • Extensive proliferation of bile ductules and edema, particularly at interface of septa and parenchyma
  • May have bile lakes, extensive feathery degeneration