Liver and intrahepatic bile ducts - nontumor
Systemic diseases / conditions
Sarcoidosis

Author: Komal Arora, M.D. (see Authors page)

Revised: 10 November 2017, last major update May 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Sarcoidosis[TI] liver[TI] full text[sb]

Cite this page: Arora, K. Sarcoidosis. PathologyOutlines.com website. http://pathologyoutlines.com/topic/liversarcoid.html. Accessed December 14th, 2017.
Definition / general
  • Need clinical information to confirm diagnosis
  • 60 - 90% have hepatic granulomas but usually subclinical
  • Occasionally associated with chronic intrahepatic cholestasis, portal hypertension, Budd-Chiari syndrome
Case reports
Microscopic (histologic) description
  • Granulomatous hepatitis with portal and lobular granulomas; granulomas are not duct centered
  • Granulomas may coalesce leading to scarring
  • Hepatic fibrosis in 21%, cirrhosis in 6%
  • Usually minimal other inflammatory cells