Home   Chapter Home   Jobs   Conferences   Fellowships   Books


Liver and intrahepatic bile ducts-nontumor

Infectious (non-viral) disorders

Reye’s syndrome

Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 12 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.


● First described in 1963 by Reye and colleagues
● Encephalopathy and fatty degeneration of liver in children due to mitochondrial dysfunction after febrile viral-like illness treated with aspirin
● Disease has almost disappeared in children as aspirin use has declined for viral-like illnesses
● Current cases are more common in adults; in children are associated with inborn errors of urea cycle or fatty acid metabolism
● Changes similar to Jamaican vomiting sickness and valproic acid toxicity

Micro description

● Diffuse, panlobular, microvesicular fatty change, no necrosis, no inflammation

Positive stains

● Fat stains

Electron macroscopy description

● Enlarged, pleomorphic mitochondria with expanded matrix and fewer mitochondrial dense bodies

Additional references

Cell Biochem Funct 2008;26:741

End of Liver and intrahepatic bile ducts-nontumor > Infectious (non-viral) disorders > Reye’s syndrome

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at [email protected] with any questions (click here for other contact information).