Liver and intrahepatic bile ducts - nontumor
Transplantation
Post bone marrow transplantation

Author: Komal Arora, M.D. (see Authors page)

Revised: 13 November 2017, last major update May 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Bone marrow transplantation[TI] liver[TI] full text[sb]

Cite this page: Arora, K. Post bone marrow transplantation. PathologyOutlines.com website. http://pathologyoutlines.com/topic/liverpostBMT.html. Accessed December 14th, 2017.
Clinical features
  • Shortly after donor marrow administration: weight gain, tenderness, edema, ascites
  • Within first 30 days: fungal and CMV infection, veno-occlusive disease or nodular regenerative hyperplasia
  • Delayed complication: focal nodular hyperplasia is frequent at median 6 years posttransplant in children (Bone Marrow Transplant 2009;43:127)
  • Poor outcome likely if severe liver toxicity or severe liver dysfunction
  • Frequent iron overload contributes to liver dysfunction (Bone Marrow Transplant 2008;42:461, Eur J Gastroenterol Hepatol 2004;16:157)
  • Death due to septicemia, pneumonia, bleeding, multiorgan failure
Laboratory
Microscopic (histologic) description