Liver and intrahepatic bile ducts - nontumor
Vascular disorders
Hepatoportal sclerosis

Author: Komal Arora, M.D. (see Authors page)

Revised: 9 November 2017, last major update May 2012

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PubMed Search: Hepatoportal sclerosis[TI]

Cite this page: Arora, K. Hepatoportal sclerosis. PathologyOutlines.com website. http://pathologyoutlines.com/topic/liverhepatoportalsclerosis.html. Accessed December 14th, 2017.
Definition / general
  • Also called portal venopathy, noncirrhotic portal fibrosis, idiopathic portal hypertension
  • Due to extrahepatic or intrahepatic portal venous obstruction, arsenic or vinyl chloride exposure
  • Causes portal hypertension without overt liver failure and variable liver function and hematologic abnormalities
  • Diagnosis is usually only "suggestive of" or "consistent with" due to patchy nature of disease

Noncirrhotic portal hypertension in HIV infected patients:
Microscopic (histologic) description
  • Patchy mural thickening, fibrotic obstruction or absence of portal veins, frequent portal vein thromboses and sclerosis
  • Bridging fibrosis between portal areas without cirrhosis, hepatocyte regeneration (nodular regenerative hyperplasia), multiple channels in portal areas with portal vein-like spaces directly abutting hepatic parenchyma
  • Parenchymal atrophy of the liver secondary to portal malperfusion