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Liver and intrahepatic bile ducts-nontumor


Chronic GVHD

Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 27 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.


● Changes occuring after post-transplant day #100
● Biopsy provides diagnosis and prognostic information
Poor prognostic features: piecemeal necrosis, fibrosis, cirrhosis

Micro description

● Brisk lymphocytic infiltrate, bile duct damage with total loss of interlobular bile ducts (vanishing bile duct syndrome), endothelialitis
● May be piecemeal necrosis but no extensive hepatocellular damage

Differential diagnosis

● Drug reaction (may also cause loss of bile ducts)

End of Liver and intrahepatic bile ducts-nontumor > Transplantation > Chronic GVHD

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