Home   Chapter Home   Jobs   Conferences   Fellowships   Books


Liver and intrahepatic bile ducts-nontumor


Acute graft rejection

Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 22 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.


● Cell mediated, potentially reversible
● Either resolves or progresses to chronic graft rejection
Banff International Consensus Document criteria: mixed portal inflammation, cholangiolitis and endothelialitis (Hepatology 1997;25:658, Hepatology 2006;44:489)


● Cautious increase in immunosuppression (even if posttransplant lymphoproliferative disorder)

Micro description

● Portal infiltrate of lymphocytes and variable eosinophils and neutrophils that damage bile ducts and venous endothelium
● No/minimal hepatocyte damage
● Also loss of bile ducts, arteritis, central ischemic damage with ballooning degeneration and hepatocyte dropout

Micro images

Moderate acute rejection with bile duct damage

Severe acute rejection

Loss of bile ducts

Differential diagnosis

EBV associated hepatitis
Hepatitis C
Primary biliary cirrhosis
Terbinafine drug reaction

End of Liver and intrahepatic bile ducts-nontumor > Transplantation > Acute graft rejection

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at [email protected] with any questions (click here for other contact information).