Liver and intrahepatic bile ducts - nontumor
Vascular disorders
Veno-occlusive disease

Author: Komal Arora, M.D. (see Authors page)

Revised: 9 November 2017, last major update May 2012

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PubMed Search: Veno-occlusive disease[TI] liver[TI] full text[sb]

Cite this page: Arora, K. Veno-occlusive disease. PathologyOutlines.com website. http://pathologyoutlines.com/topic/liverVOD.html. Accessed December 16th, 2017.
Definition / general
  • Originally in Jamaican drinkers of pyrrolizidine alkaloid containing bush tea
  • Now occurs after a few weeks in 25% with allogeneic bone marrow transplant; 30% mortality; biopsy is risky in these patients
  • Symptoms: tender hepatomegaly, ascites, weight gain, jaundice
  • Treatment: supportive
Case reports
Microscopic (histologic) description
  • Obliteration of central vein (terminal hepatic venule) radicles by subendothelial swelling and fine reticulated collagen
  • Acutely is centrilobular congestion / necrosis with hemosiderin laden macrophages
  • Later, obliteration of lumen is noted with reticulin stain; very late - may see obliteration of the venule
Microscopic (histologic) images

Images hosted on other servers:

Fibrous occlusion
of centrilobular
venule (silver stain)