Liver and intrahepatic bile ducts-nontumor
Heme oxygenase-1 deficiency
Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 30 April 2012, last major update April 2012
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● Enzyme degrades heme into biliverdin, carbon monoxide and free iron; also is anti-oxidant, and has role in iron balance (J Cell Mol Med 2009;13:3091)
● 6 year old boy with growth retardation, anemia, other laboratory abnormalities (Hum Pathol 2002;33:125)
● Amyloid present in liver and adrenal glands, mesangioproliferative glomerular changes in kidney, fatty streaks and fibrous plaques in aorta
End of Liver and intrahepatic bile ducts-nontumor > Metabolic diseases > Heme oxygenase-1 deficiency
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