Kidney tumor - cysts, children, adult benign
Benign (usually) adult tumors
Sinus histiocytosis with massive lymphadenopathy

Author: Mandolin Ziadie, M.D. (see Authors page)

Revised: 30 January 2017, last major update March 2012

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PubMed Search: Sinus histiocytosis massive lymphadenopathy kidney

Cite this page: Sinus histiocytosis with massive lymphadenopathy. PathologyOutlines.com website. http://pathologyoutlines.com/topic/kidneytumorsinushistiocytosis.html. Accessed April 26th, 2017.
Definition / General
Epidemiology
  • Rare disease with even rarer involvement of kidney
  • More common in children and young adults
Clinical Features
  • Fever, leukocytosis, anemia, elevated sedimentation rate and polyclonal hypergammaglobulinemia
  • Relatively favorable prognosis
  • Poor prognostic factors include multiple organ involvement, disseminated nodal disease and systemic immunologic disorder
Case Reports
Gross Description
  • Pelvic / sinus mass with multinodular, tanish yellow or gray hemorrhagic cut surface (may appear similar to renal cell carcinoma)
Gross Images

Images hosted on other servers:

Well circumscribed mass
with a creamy brownish
appearance

Micro Description
  • Tissue infiltration by sheets of large histiocytes with granular eosinophilic cytoplasm, large, round and vesicular nuclei, prominent nucleoli and accompanied by plasma cells and lymphocytes
  • Extensive emperipolesis (histiocytes with intracytoplasmic lymphocytes)
Micro Images

Images hosted on other servers:

Emperipolesis in various disorders

Various images

S100+

Lymphoid infiltrate surrounding
scattered large histiocytic cells
containing phagocytosed intracytoplasmic
lymphocytes (arrows)

Positive Stains
Negative Stains