Kidney tumor - cysts, children, adult benign
Childhood neoplasms
Oncocytoid renal cell carcinoma after neuroblastoma

Author: Mandolin Ziadie, M.D. (see Authors page)

Revised: 17 January 2017, last major update January 2012

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PubMed Search: Oncocytoid renal cell carcinoma neuroblastoma kidney

Cite this page: Oncocytoid renal cell carcinoma after neuroblastoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/kidneytumoroncocytoidRCC.html. Accessed July 24th, 2017.
Definition / general
Clinical features
  • 4 cases described with mean age 9 years, range 5 - 13 years
  • Mean interval between neuroblastoma and carcinoma of 7 years (range 3 - 12 years)
Microscopic (histologic) description
  • Expansile masses of large cells with well defined cell membranes
  • Abundant eosinophilic, oncocytic or reticular cytoplasm
  • Enlarged nuclei with mildly irregular contours, distinct nucleoli
  • Occasional lipid laden histiocytes, psammoma bodies and mitotic figures
  • Cells arranged in solid and papillary patterns
  • May resemble high grade papillary renal cell carcinoma but predominantly solid and without necrosis
Microscopic (histologic) images

Images hosted on other servers:

Nature.com images:

Various images

Positive stains
Negative stains
Molecular / cytogenetics description
  • 14q31 and 20q13 abnormalities
  • Also other changes not typical for renal cell carcinoma
Electron microscopy description
  • Microvilli and cell junctions, less mitochondria than oncocytoma
  • No microvesicles