Kidney tumor - cysts, children, adult benign
Cystic nonneoplastic lesions
Mesothelial cysts

Author: Mandolin Ziadie, M.D. (see Authors page)

Revised: 9 January 2017, last major update December 2011

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PubMed Search: Mesothelial cysts kidney

Cite this page: Mesothelial cysts. PathologyOutlines.com website. http://pathologyoutlines.com/topic/kidneytumormesothelialcyst.html. Accessed January 20th, 2017.
Definition / General
  • Rare; cysts lined by mesothelial cells in vicinity of kidney that may present as renal masses
  • Also called primary retroperitoneal cysts of mesothelial origin
Radiology Images

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Figure 1A: MRI shows cystic mass (arrows) involving upper pole;
fig 1B: cystic mass (arrows) at lower pole

Gross Description
  • Thin walled, unilocular cyst filled with clear fluid
  • May be hemorrhagic
Gross Images

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Fig A / B: hemorrhagic unilocular cysts

Micro Description
  • Thin walled cyst lined by single cell lining of nonpleomorphic cells with abundant eosinophilic cytoplasm, vesicular nuclei and small nucleoli
  • May have small gland-like spaces
Micro Images

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Cyst lining cells have
abundant eosinophilic
cytoplasm, vesicular
nuclei and small nucleoli

Cyst lining cells are
CEA–, keratin+,
HBME1+ and WT1+

Negative Stains
Differential Diagnosis
  • Lymphangioma: multicystic, has smooth muscle and lymphocytes in cyst wall and lumen, keratin+
  • Mucinous cystadenoma: ovarian-like stroma, mucin+, CEA+, negative for hyaluronic acid
  • Simple hemorrhagic cyst
Additional References