Kidney tumor
Renal pelvic tumors
Squamous cell carcinoma

Author: Nicole K. Andeen, M.D. (see Authors page)
Editor: Maria Tretiakova, M.D.

Revised: 3 February 2017, last major update July 2015

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: Squamous cell carcinoma [title] kidney

Cite this page: Squamous cell carcinoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/kidneytumormalignantsquamous.html. Accessed April 23rd, 2017.
Definition / General
  • Pure squamous cell carcinoma, with no evidence of urothelial differentiation (invasive or in situ) and not combined with another renal neoplasm
Terminology
  • Cases with associated urothelial carcinoma or urothelial carcinoma in situ are best classified as urothelial carcinoma with squamous differentiation
Epidemiology
  • Very rare tumor, except for patients with nonfunctioning hydronephrotic kidney due to renal pelvic stone disease (Mol Clin Oncol 2015;3:941)
  • Approximately equal men and women, age 50 - 70 years (J Urol 2007;178:51)
Etiology
  • Hypothesized to originate from squamous metaplasia in response to chronic irritation due to recurrent urinary tract infections, vesicoureteral reflux, longstanding renal calculi, smoking, schistosomiasis or chemical exposure (J Urol 2010;183:2023, Case Reports Pathol 2014:256813)
  • However, some cases reported without these associations
Clinical Features
  • Hematuria, abdominal pain
  • May produce paraneoplastic syndrome with hypercalcemia, similar to squamous carcinoma of lung (Urology 2014;84:8)
Prognostic Factors
Case Reports
Clinical Images

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Coronal and axial ultrasound

Computed tomography

Solitary mass lower right kidney

Mass in right renal pelvis

Gross Description
  • Large, solid and necrotic tumor
Gross Images

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Dilated renal calyces due to reflux

Solid, tanish white with central necrosis

Associated with kidney stones

Left renal pelvic tumor

Micro Description
  • Demonstrates features of squamous carcinomas seen at other sites: intracellular bridges, keratin pearls, keratinaceous cellular debris
Micro Images

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Low power

Entrapped glomeruli

No urothelial differentiation

20×

Entrapped renal tubules


Keratin pearl formation

Poorly differentiated

SCC with keratin pearls

Resected renal pelvic tumor

CK5 / 6, p53, CK7

Electron Microscopy Description
  • Similar to other squamous cell carcinoma
Electron Microscopy Images

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Many desmosomes
and cytoplasmic
tonofilaments

Differential Diagnosis
Additional References