Kidney tumor
Renal pelvic tumors
Adenocarcinoma of renal pelvis

Authors: Sean Williamson, M.D. (see Authors page)

Revised: 3 February 2017, last major update June 2012

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: Adenocarcinoma renal pelvis [title] kidney
Cite this page: Adenocarcinoma of renal pelvis. PathologyOutlines.com website. http://pathologyoutlines.com/topic/kidneytumormalignantrenaladenoca.html. Accessed September 20th, 2017.
Definition / general
  • Rare neoplasm (1%) of renal pelvis originating from urothelium with pure glandular differentiation
Epidemiology
  • Most primary renal neoplasms of renal pelvis are urothelial carcinomas; urothelial carcinoma with glandular differentiation is more common than pure adenocarcinoma
  • A link between adenocarcinoma and pyelitis glandularis / pyelitis cystica, secondary to chronic inflammation or renal stones, is controversial (Urology 2008;71:915, Clin Cancer Res 2007;13:6232)
Case reports
Gross description
  • Large, infiltrating tumor, which fills dilated renal pelvis and calyces and invades adjacent renal parenchyma
Gross images

Images hosted on PathOut server:

Case of the Week #397 - Horseshoe kidney with papillary mucinous cystadenocarcinoma of renal pelvis:

Close up of opened renal pelvis cyst

Cyst wall section showing papillary projections

Atrophic, hydronephrotic
kidney parenchyma
with renal pelvis cyst



Case of the Week #94 - Signet ring cell adenocarcinoma:

Various images

Microscopic (histologic) description
Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #397 - Horseshoe kidney with papillary mucinous cystadenocarcinoma of renal pelvis:

Cyst wall (4×)

Background renal parenchyma (10×)

Cyst lining (10×)

Cyst wall (10×)

Mucin (10×)

Cyst lining (20×)



Case of the Week #94 - Signet ring cell adenocarcinoma:

Rhabdoid features and intracytoplasmic lumina

Signet ring cells

Superficial invasion by tumor cells

With goblet cell metaplasia

Mucin+ with PAS Alcian blue stain

Positive stains
Differential diagnosis
  • Metastasis or direct extension: exclusion is critical (colorectal, stomach, breast or others)
  • Urothelial carcinoma with glandular differentiation: shows admixture of typical urothelial carcinoma and glandular component