Kidney tumor - Adult malignancies
Other neoplasms - Adult or adult / child
Angiosarcoma

Author: Sean Williamson, M.D. (see Authors page)

Revised: 7 February 2017, last major update June 2012

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: Angiosarcoma kidney

Cite this page: Angiosarcoma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/kidneytumormalignantangiosarcoma.html. Accessed February 22nd, 2017.
Definition / General
  • Malignant vascular tumor with anastomosing vascular spaces lined by atypical endothelial cells
  • Very rare as primary kidney tumor (< 50 cases reported), almost all men, more often left sided, presenting with hematuria, flank pain or palpable mass; metastasis to the kidney from a primary site elsewhere (such as skin) is also rare
  • Poor prognosis (Am J Surg Pathol 2010:34:942)
  • Risk factors at other sites include exposure to arsenic, Thorotrast, polyvinyl chloride or radiation; also posttreatment lymphedema
Case Reports
Gross Images

Images hosted on PathOut server:

Multiple hemorrhagic masses

Micro Description
  • Infiltrative, often with extensive destruction of the parenchyma, at least small areas of vasoformative growth (Am J Surg Pathol 2010:34:942), although spindled / epithelioid growth may be prominent
Micro Images

Images hosted on PathOut server:

Numerous blood filled vascular spaces



Images hosted on other servers:

Anastomosing vascular channels with minimal atypia

Endothelial cells in compact sheets

Cytology Description
  • Highly pleomorphic cells, some containing hemosiderin
  • Neovascular structures with intracytoplasmic lumina containing erythrocytes
  • Cells are noncohesive with long cytoplasmic processes
  • Erythrophagocytosis is present; variable cellularity due to necrosis
Cytology Images

Images hosted on other servers:

50 year old man: various images

Electron Microscopy Description
  • Spindle cells with abundant pinocytotic vesicles, intermediate filaments, rare Weibel-Palade bodies
Differential Diagnosis