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Kidney non-tumor

Blood vessel disorders

Sickle cell disease nephropathy

Reviewers: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 25 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Sickle cell trait or disease causes hematuria, decreased concentrating ability
● May be due to ischemia in hypertonic, hypoxic renal medulla due to plugging of vessels in vasa recta
● Mild proteinuria in 30%

Gross images

Necrotizing papillitis

Micro description

● Patchy papillary necrosis
● Occlusion of glomeruli by sickled cells
● Extensive congestion and sickling in peritubular capillaries

Micro images

Sickle cell nephropathy

Case report of collapsing glomerulopathy

Electron microscopy images

Sickle red cells inside glomerular capillary loop

End of Kidney non-tumor > Blood vessel disorders > Sickle cell disease nephropathy

Ref Updated: 8/28/12

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