Kidney nontumor
General
Physiology of kidney

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 12 September 2017, last major update April 2012

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PubMed Search: Physiology of kidney "loattrfree full text"[sb] non-tumor

Cite this page: Sangle, N. Physiology of kidney. PathologyOutlines.com website. http://pathologyoutlines.com/topic/kidneyphysiology.html. Accessed October 24th, 2017.
Definition / general
  • Filters 1700 L of blood to 1 L of urine per day
  • Excretes metabolic waste; regulates water, salt, and pH
  • Secretes renin, prostaglandins and erythropoietin
  • Nephron production ceases at birth, there are 1.3 million/kidney
  • Renal intercalated cells may regulate pH through expression of soluble adenylate cyclase, a sensor that detects luminal bicarbonate and activates the vacuolar proton pumping ATPase via cAMP (Am J Physiol Cell Physiol 2012;302:C1421)
  • Nephron: glomerulus filters blood, ultrafiltrate enters Bowman’s space, filtrate enters proximal convoluted tubule, to pars recta of proximal tubule, to thin descending limp of loop of Henle, to thick ascending limb of loop of Henle, to macula densa (adjacent to glomerulus), to distal convoluted tubule, to collecting tubule, to collecting duct of Bellini and to calyx (Wikipedia: Renal physiology)
  • Clearance: amount of plasma cleared of a substance per minute to appear in urine
Diagrams / tables

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Details on physiology