Kidney nontumor / medical renal
Tubulointerstitial disease
Drug and toxin related tubulointerstitial injury
Indinavir nephropathy
Author: Nikhil Sangle, M.D.
Last author update: 3 September 2012
Last staff update: 20 September 2023
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: Indinavir nephropathy pathology
Table of Contents
Definition / general | Case reports | Treatment | Microscopic (histologic) images | Electron microscopy imagesCite this page: Sangle N. Indinavir nephropathy. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/kidneyindinavir.html. Accessed April 18th, 2024.
Definition / general
- Protease inhibitor used to treat HIV, strongly associated with direct nephrotoxicity (Adv Chronic Kidney Dis 2010;17:72)
- May cause tubulointerstitial nephritis due to intratubular precipitation of indinavir crystals, with damage to tubular epithelial cells and histiocytic reaction
- Tolerance may be higher in those from sub Saharan Africa versus US / Europe (AIDS Res Hum Retroviruses 2007;23:62)
- May resemble tuberculosis (Braz J Infect Dis 2008;12:99)
Case reports
- 49 year old man with HIV and indinavir induced nephrolithiasis 3 years after discontinuing indinavir (Int Urol Nephrol 2011;43:571)
Treatment
- Dose reduction (Eur J Clin Pharmacol 2007;63:901), discontinuation, urine acidification, early insertion of bilateral double J ureteral stents (Int Urol Nephrol 2007;39:743)
Microscopic (histologic) images
Images hosted on other servers:
Biopsy findings
Crystal induced tubular injury
Indinavir crystals in urinary sediment
Electron microscopy images
Images hosted on other servers:
Granulomatous giant
cell reaction with
crystals within lumen
