Kidney nontumor
Primary glomerular diseases
Collapsing glomerulopathy

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 15 September 2017, last major update September 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Collapsing glomerulopathy [title]

Cite this page: Sangle, N. Collapsing glomerulopathy. PathologyOutlines.com website. http://pathologyoutlines.com/topic/kidneycollapsingglomerulo.html. Accessed October 23rd, 2017.
Definition / general
Case reports
Microscopic (histologic) description
  • Accentuation of lobules due to widespread collapse of glomerular capillary loops with localized hyperplasia and hypertrophy of epithelial cells overlying sclerotic segment
  • Cells are vacuolated and swollen, contain abundant resorption droplets
  • Severe tubulointerstitial injury with degenerative changes, dilated tubules, tubular casts and lymphocytic infiltrate
Microscopic (histologic) images

Images hosted on other servers:

Collapsed glomerulus

With sickle cell disease

Various images

Immunofluorescence
  • Segmental IgM and C3
Electron microscopy description
  • Wrinkling but little / no basement membrane thickening; marked podocyte hypertrophy; no electron dense deposits of tubuloreticular inclusions (compared to HIV associated nephropathy)