Cite this page: Shankar, V. Scleroderma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/jointsscleroderma.html. Accessed October 22nd, 2017.
- Also called progressive systemic sclerosis
- Initially presents with nonspecific joint pains which can lead to arthritis
- Joint mobility may be restricted by calcinosis or skin thickening
- May be accompanied or even dominated by arthritis and arthralgia
- Serum positive for rheumatoid factor and anticentromere antibodies (Br J Rheumatol 1995;34:831)
Microscopic (histologic) description
- Superficial fibrin deposition in synovial membrane, mild mononuclear infiltrate, mild synovial hyperplasia, proliferation of collagen fibers, focal obliteration of small vessels