Joints
Noninfective arthritis
Scleroderma

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 29 August 2017, last major update May 2013

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Scleroderma [title] joints

Cite this page: Shankar, V. Scleroderma. PathologyOutlines.com website. http://pathologyoutlines.com/topic/jointsscleroderma.html. Accessed October 22nd, 2017.
Clinical features
  • Also called progressive systemic sclerosis
  • Initially presents with nonspecific joint pains which can lead to arthritis
  • Joint mobility may be restricted by calcinosis or skin thickening
  • May be accompanied or even dominated by arthritis and arthralgia
  • Serum positive for rheumatoid factor and anticentromere antibodies (Br J Rheumatol 1995;34:831)
Microscopic (histologic) description
  • Superficial fibrin deposition in synovial membrane, mild mononuclear infiltrate, mild synovial hyperplasia, proliferation of collagen fibers, focal obliteration of small vessels