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Benign gallbladder tumors

Signet ring cells

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 16 February 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.


● Represent hyperplastic and degenerative change of mucosal goblet cells, non-neoplastic (Hum Pathol 2009;40:326)
● Seen on mucosal surface and lumen of tubules

Micro description

● Signet ring cells that lack nuclear atypia, arranged in superficial and intraluminal nests
● Admixture with histiocytes and other inflammatory cells

Micro images

Signet-ring cells in gallbladder wall immediately beneath mucosa

Signet-ring cells arranged in nodular collections within glandular lumina surrounded by lamina propria; are AE1-AE3+

Positive stains

● Mayer's mucicarmine; AE1/AE3

Differential diagnosis

● Signet ring cell carcinoma

End of Gallbladder > Benign gallbladder tumors > Signet ring cells

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