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Extrahepatic bile ducts

Normal histology-extrahepatic bile ducts

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 12 February 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.


● May want to submit entire specimen
● Submit margins separately, including hepatic margin (if liver tissue present)


Surface epithelium:
● Composed of tall, uniform, columnar cells
● Mucosa forms irregular pleats or small longitudinal folds

Peribiliary mucous glands:
● Considered a local progenitor cell niche in extrahepatic biliary epithelium (Liver Int 2012;32:554)
● Unevenly distributed within large intrahepatic ducts and all extrahepatic bile ducts
● Lobular architecture; are surrounded by fibroconnective tissue (important in differentiating from well differentiated carcinoma)

Subepithelial region:
● Dense, hypocellular connective tissue, few lymphocytes
● Overlies loose connective tissue with elastic fibers and smooth muscle fibers that are most prominent distally but absent or sparse proximally

Muscle layer:
● Not well defined until distal common bile duct / lower 1/3 of extrahepatic bile duct (Am J Surg Pathol 2000;24:660)
● Upper 1/3 has no muscle layer or scattered muscle fibers

Micro images

Various images

Positive stains

Peribiliary glands: amylase, trypsin, lipase

End of Extrahepatic bile ducts > Normal histology-extrahepatic bile ducts

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